2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130283
    Methyltetrazine-Ph-NHS ester 1644644-96-1 98.92%
    Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-Ph-NHS ester
  • HY-140452
    Azido-PEG2-C2-acid 1312309-63-9 98.0%
    Azido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C2-acid
  • HY-140212
    Azido-PEG1-amine 464190-91-8 98.0%
    Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-amine
  • HY-140736
    DSPE-PEG-Biotin, MW 2000 385437-57-0 99.93%
    DSPE-PEG-Biotin, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-Biotin, MW 2000
  • HY-140941
    Biotin-PEG2-C2-iodoacetamide 292843-75-5 98.23%
    Biotin-PEG2-C2-iodoacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-C2-iodoacetamide
  • HY-108374
    4-Azidobutylamine 88192-20-5 98.0%
    4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    4-Azidobutylamine
  • HY-130485
    Bromo-PEG2-C2-azide 530151-56-5 98.70%
    Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG2-C2-azide
  • HY-130653
    Azido-PEG4-C2-acid 1257063-35-6 99.20%
    Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-C2-acid
  • HY-140755
    Aeide-C1-NHS ester 824426-32-6 98.0%
    Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Aeide-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aeide-C1-NHS ester
  • HY-130907
    Fmoc-N-PEG24-acid 2170484-59-8 99.91%
    Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-PEG24-acid
  • HY-141167A
    TCO-PEG4-NHS ester 1621096-79-4 99.16%
    TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG4-NHS ester
  • HY-123916
    DBCO-Biotin 1418217-95-4 98.49%
    DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-Biotin
  • HY-W008352
    Boc-NH-PEG4-CH2CH2NH2 811442-84-9 ≥98.0%
    Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-CH2CH2NH2
  • HY-140764
    Azido-PEG3-NHS ester 1092654-47-1 ≥98.0%
    Azido-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-NHS ester
  • HY-42490
    N3-PEG3-CH2CH2COOH 1056024-94-2 ≥98.0%
    N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG3-CH2CH2COOH
  • HY-151716
    Halo-DBCO 1808119-16-5 98.25%
    Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples.
    Halo-DBCO
  • HY-117009
    Bis-PEG9-NHS ester 1008402-79-6 98.0%
    Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG9-NHS ester
  • HY-W096093
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 1035373-85-3 99.71%
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride
  • HY-140274
    DBCO-PEG12-NHS ester 2093934-94-0 ≥99.0%
    DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG12-NHS ester
  • HY-130291
    Biotin-PEG3-NHS ester 1253286-56-4 99.35%
    Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG3-NHS ester
PROTAC Linkers Isoform Comparison

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